Engineered natural Tregs
Engineered natural Tregs
Broad, durable immune control with simple, outpatient delivery – the potential for life-changing efficacy with benign safety.
CHILL
Our thesis
CHILL
Autoimmune disease is driven by many immune cell types working together, not a single culprit.
Broad control. Quell's engineered nTregs are designed to restore broad control across multiple cell types involved in complex autoimmune inflammation, including autoreactive T and B cells and inflammatory cytokines, and to steer macrophages and fibroblasts towards tissue repair.
Read more about our pre-clinical working demonstrating the modulation activity of our engineered nTreg cells across multiple immune cell types.
Built-in stability. Our Phenotype-Lock™ technology is designed to keep nTregs stable, even under inflammatory stress, without producing pro-inflammatory cytokines to avoid the toxicities linked to cell-depleting therapies, such as cytokine release syndrome (CRS) or local immune effector cell-associated toxicity syndrome (LICATS).
Manufacturing
A world-leading nTreg process
With deep GMP experience we pride ourselves on the continued delivery of the highest manufacturing standards. Our world leading proprietary manufacturing process is built upon a deep understanding of Treg biology and our experience at therapeutic scale, with several hundred scale runs, has driven significant improvements, making our manufacturing process highly efficient, stable, and effective for delivering transformative cell products to patients.
Publications
Publications & presentations
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